Endocrine Abstracts

SH is defined by a decrease of TSH with normal thyroid hormone (TH) concentrations. The clinical picture is not clear, whether these patients may have symptoms or alterations of QoL. It is well known that in overt hyperthyroidism, symptoms may be absent in old patients. In SH, one study in young patients has reported an increased symptom score and a slight decrease of QoL but these results have not been confirmed in middle-aged subjects. We report the initial data of the Pirat...

Introduction: In type 1 multiple endocrine neoplasia (MEN1), primary hyperparathyroidism (PHPT) is a challenging problem due to the high post-surgery recurrence rate. Cinacalcet is a calcimimetic agent which showed to be effective in patients in whom surgery is contraindicated or refused. In this study we assessed the efficacy and the safeness of cinacalcet in MEN1 patients, in comparison with patients with sporadic PHPT (sPHPT). Moreover, the influence of Arg990Gly CASR polym...